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吴李君

作者:    新闻来源:    发布时间:2011-08-18
吴李君:   研究方向包括低剂量辐射遗传损伤的细胞和分子基础,损伤信号在细胞和组织间的传递及其生物学响应,环境因子与生物体相互作用以及特异性损伤标记物等。 
(一)科研项目

1.国家“863”重点项目“环境污染的健康风险评估和控制关键技术”(2008.9-2011.9),

  项目号:2008AA062504,副课题组长。

2.国家重大科学研究计划项目“面向持久性有毒污染物痕量检测与治理的纳米材料应用基础

  研究”子课题“纳米材料表面生化修饰与POPs的选择性富集”(2007.10-2012.10),项目

  号:2007CB936602,参加。

3.国家自然科学基金面上项目“p21和Hus1在介导辐射损伤信号产生与传导以及旁效应中的

  作用研究”(2008.1-2010.12),基金项目号:30770504,主持。

4.国家自然科学基金面上项目“高氯化钠环境对细胞辐射旁效应传导的影响”

  (2006.1-2008.12),基金项目号:30570435,主持。

5.国家杰出青年科学基金“辐射损伤及其生物学基础研究-核技术及其应用”

  (2003.1-2006.12),基金项目号:10225526,主持。

6.国家自然科学基金面上项目“离子注入模拟环境低能粒子对哺乳动物细胞的影响”

  (2002.1-2004.12),基金项目号:30170234,主持。

7.国家自然科学基金面上项目“辐射引起细胞近旁效应的机理研究”(2001.1-2003.12),

  基金项目号:30070192,主持。

(二)获奖和社会兼职

1.国家自然科学基金委员会第十二届学科评审组成员。

2.中国生物物理学会理事,环境与辐射生物物理专业委员会主任(2006年6月-2010年5月)。

3.中国毒理学会理事。

4.《Mutation Research》和《生物物理学报》编委。

5.获国家发明奖二等奖(“低能离子束细胞修饰技术和装置”,2006年,第三完成人)。

6.获安徽省自然科学一等奖(“精确放射治疗相关科学问题研究”,2006年,第五完成人)。

7.获安徽省自然科学一等奖(“离子束介导的转基因研究”,2000年,第三完成人)。

8.获中国科学院研究生院长奖学金特别奖,1999年。

(三)近期发表的代表性研究论文(*通讯作者)

1.Gen Yang, Lijun Wu*, Shaopeng Chen, Lingyan Zhu, Pei Huang, Liping Tong, Ye Zhao, Guoping Zhao, Jun Wang, Tao Mei, An Xu and Yugang Wang*, Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect, British Journal of Cancer, Accepted, 2009.

2.Lingzhi Bao, An Xu, Liping Tong, Shaopeng Chen, Lingyan Zhu, Ye Zhao, Guoping Zhao, Erkang Jiang, Jun Wang and Lijun Wu*, Activated Genotoxicity of Diesel Particulate Extract by Ultraviolet A Irradiation in Mammalian Cells: Role of Singlet Oxygen, Environmental Health Perspectives, 117(3): 437-441, 2009.

3.Erkang Jiang, Lingyan Zhu, Jun Wang, Shaopeng Chen, Linzhi Bao, Ye Zhao, Root Yang,Guoping zhao, An Xu, Zengliang Yu and Lijun Wu*, Enhanced Radiation Damage in Irradiated and Non-irradiated BystanderCells by Co-exposure with Myosmine, Mutation Research, 672: 60-64, 2009.

4.Lingyan Zhu, Wei Han, Shaopeng Chen, Ye Zhao, Jun Wang, Erkang Jiang,  Linzhi Bao, An Xu, Zengliang Yu and Lijun Wu*, Elevated sodium chloride concentration enhances bystander effects by increasing the sensitivity of bystander cells to the signals released from irradiated cells, Mutation Research, 644, 43–47, 2008.

5.Bei Pei, Shunchang Wang, Xiaoyin Guo, Jun Wang, Haiying Hang and Lijun Wu*, Arsenite-induced germ cell apoptosis through a MAPKs-dependent, p53- independent pathway in Caenorhabditis elegans,Chemical Research in Toxicology, 21, 1530–1535, 2008. [Highlight in “in This Issue” of Chemical Research in Toxicology, 21, (2008)]

6.Shaopeng Chen, Ye Zhao, Guoping Zhao, Lingyan Zhu, Jun Wang, Linzhi Bao, Erkang Jiang, An Xu, Tom K Hei, Zengliang Yu and Lijun Wu*, Mitochondria-depended Signaling Pathway Involving in the Early Process of Radiation Induced Bystander Effects, British Journal of Cancer, 98: 1839-1844, 2008. [Highlighted by Jasmine Farsarakis in “Cancer therapy: Effects of radiation. Nature China (2008)]

7.Shunchang Wang, Minli Tang, Bei Pei, Xiang Xiao, Jun Wang, Haiying Hang,  and Lijun Wu*, Cadmium induced germline apoptosis in Caenorhabditis elegans: the roles of HUS1, p53 and MAPK signaling pathways, Toxicological Sciences, 102: 345-351, 2008.

8.Wei Han, Lingyan Zhu, Erkang Jiang, Jun Wang, Shaopeng Chen,  Linzhi Bao, Ye Zhao, An Xu, Zengliang Yu and Lijun Wu*, Elevated sodium chloride concentrations enhance the bystander effects induced by low dose alpha-particle irradiation, Mutation Research,  624/1-2: 124-131, 2007.

9.Wei Han, Lijun Wu*, Shaopeng Chen, Lingzhi Bao, Leilei Zhang, Erkang Jiang, Ann Xu, Tom K Hei and Zengliang Yu, Constitutive  Nitric Oxide Acting as the Possible Intercellular Signaling Molecule  in the Initiation of Radiation Induced DNA Double Strand Breaks in  Non-irradiated Bystander Cells, Oncogene, 26: 2330-2339, 2007.

10.Shunchang Wang, Ye Zhao, Lijun Wu*, Mingli Tang, Caixing Su,  Tom K. Hei and Zengliang Yu, Induction of Germline Cell Cycle  Arrest and Apoptosis by Sodium Arsenite in Caenorhabditis  elegans, Chemical Research in Toxicology, 20(2): 181-186, 2007.

12.Gen Yang, Lijun Wu*, Lianyun Chen, Jun Li, Yugang Wang,   Yuejin Wu and Zengliang Yu, Targeted Irradiation of Shoot Apical Meristem of Arabidopsis Embryo Induces long distance bystander/Abscopal Effects, Radiation Research, 167(3): 298-305, 2007.

13.Burong Hu, Lijun Wu*, Wei Han, Leilei Zhang, shaopeng Chen,  An Xu,Tom K Hei and Zengliang Yu, The time and spatial effects  of bystander response in mammalian cells induced by low dose  radiation, Carcinogenesis, 27(2): 245-251, 2006.

14.Burong Hu, Wei Han, Lijun Wu*, Huiyun Feng, Xuelan Liu, Leilei Zhang, An Xu,  T K Hei and Zengliang Yu, In situ visualization of DSBs to assess the  extranuclear/extracellular effects induced by low dose α-particle  irradiation, Radiation Research, 164(3): 286-293, 2005.